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December 6, 2022
Topics
Ada Cavalcanti-Adam will give a seminar in DWI (seminar room, 1st floor). The seminar will be about cell-cell and cell-matrix interactions – how cells sense forces, how proteins in the cell react to forces and how this can be used for our US approaches. So-called mechanosensitive proteins are ideal naturally occurring candidates to be activated in vivo using US. An especially suiting protein could for example be talin with its 13 mechanical switches (https://journals.biologists.com/jcs/article/134/20/jcs258749/272649/Talin-in-mechanotransduction-and-mechanomemory-at). One could imagine using talin as an information-storing molecule depending on its contractility: Each of the 13 mechanical switches opens and closes at distinct force thresholds.
In her talk prior to our discussions, Ada will introduce cell receptors and regulation of cell mechanics. The talk is split in two parts: the first is on cell-matrix adhesion, the second on cell-cell adhesion.
The talk + discussions will be from 9-11 am.
November 06-09, 2022
Topics
We are delighted to invite you to participate in the 4th International Symposium on Mechanobiology (ISMB) organized and hosted by the Australian Society for Mechanobiology (AuSMB). The conference will be co-hosted by the University of Sydney Nano Institute and take place at the Sydney Nanoscience Hub at the University of Sydney, Australia, from the 6th to the 9th of November 2022.
This conference started in 2011 with the founding of the Society in Shanghai, China, and has occurred every three years also visiting Okayama (2014) and more recently Singapore (2017). This is the first time this conference is being held in Australia.
October 27, 2022
Speaker:
Daniel Heath
Department of Biomedical Engineering, The University of Melbourne
https://findanexpert.unimelb.edu.au/profile/664526-daniel-heath
Topics
Biomaterials are critical toward the development of successful biomedical devices, tissue engineering scaffolds, and organ on a chip models. In this talk, we will discuss the design, fabrication, and utilization of biomaterials for two specific applications: blood contacting biomedical devices and substrates for improved expansion of mesenchymal stem cell.
In particular, we will describe methods of producing fully defined polymeric materials that promote endothelialization and the development of extracellular matrix-derived materials that help maintain the stem cell potency and phenotype during expansion. Time permitting, we will also discuss novel selenium-based nanomaterials with antimicrobial properties to fight drug resistant bacteria.
On site:
Seminarraum B1.72
DWI – Leibniz-Institut für Interaktive Materialien
Forckenbeckstraße 50, 52074 Aachen
Link:
Zoom-Link:
https://rwth.zoom.us/j/94116853726?pwd=RUpxUFp2dDgwTWh6VGhMbHRFVnl1dz09
Meeting-ID: 941 1685 3726
Kenncode: 618817
Host:
Jacopo Di Russo
Institute of Molecular and Cellular Anatomy
Contact:
October 18, 2022
Speaker:
Prof. Dr. Gerjo van Osch
Erasmus University Medical Center, Rotterdam
Topics
“We aim to understand what limits connective tissue repair and search for methods to improve it. The ultimate goal is to stimulate the body's intrinsic repair capacity or to tissue engineer cartilage or bone outside the body, that can be used for transplantation. We investigate how to control the formation of good quality cartilage and bone (which cells, which stimuli, which biomaterials) and the role of the immune system on tissue repair. Thereby, we focus on cellular processes in cell differentiation (in particular stem cells) and inflammation. Our translational research is performed from a cell biological viewpoint using principles of developmental biology, patho-physiology, and tissue engineering.”
On site:
AVT - aachener verfahrenstechnik (NGP² HS-A-005)
Forckenbeckstraße 51, 52074 Aachen
Host:
Laura De Laporte
DWI – Leibniz-Institut für Interaktive Materialien
Contact:
October 04-06, 2022
Speaker:
Jörg Großhans, Lukas Windgaße, Lisa Müller, Thomas Magin, Sandra Iden, Marcin Moch, Andreas Janshoff, Tanmaya Sethi, Robin Püllen, Lena Thiess, Ana Díaz Álvarez, Elisabeth Butz, Matthias Rübsam, Patrizia Kroll, Jing Wang, Anne Classen, Alba Diz-Muñoz, Alicia Lardennois, Hans-Joachim Schnittler, Ngo Anh Phuong, Michael Krahn, Ann-Christin Groh
Topics
Epithelia line organ and body surfaces to provide structural support and serve as barriers against mechanical force, pathogens, toxins, and dehydration. These functions depend on the ability of intercellular junctions to sense and integrate mechanical forces and chemical signals. They transmit these into the cell to direct rapid changes in cell architecture and/or transcriptional programming thus directing cellular behaviour. Dysfunction of epithelial cell junctions causes a large number of disorders, ranging from blistering skin disease to inflammatory disorders and cancer. Despite their large size, abundance and significance in disease, epithelial intercellular junctions remain poorly understood, precluding the development of molecular diagnosis and therapies. Understanding how intercellular junctions sense force and chemical signals, how signals are integrated at junctions to elicit cellular responses at a mechanistic level is central to comprehend control of tissue morphogenesis, homeostasis and regeneration. Further, elucidating how genetic defects in intercellular junction components by-pass junction-mediated control of epithelial tissue integrity, is a prerequisite to understand the basis of multiple disorders.
On site:
Elisenbrunnen, Friedrich-Wilhelm-Platz 14, 52062 Aachen
Hörsaal (Raum 130), Medizinisch-Technisches Institut 1 (MTI-1), Wendlingweg 2, 52074 Aachen
Hotel Novotel Aachen City, Peterstraße 66, 52062 Aachen
Host:
Rudolf Leube
Institute of Molecular and Cellular Anatomy
Contact:
September 28-30, 2022
Speakers:
A Clark (Germany), J FeruzziI (USA), P Friedl (USA), H Hanenberg (Germany), CP Heisenberg (Austria), YW Yun (USA), C Leduc (France), R Leube (Germany), C Mark (Germany), AE Markaki (Great Britain), D Odde (USA), C Reinhart-king(USA), TE SCHÄFFER (Germany), S Schürle-Finke (Switzerland), U Schwarz (Germany), C Storm (The Netherlands), ED. Tabdanov (USA), D Wirtz (USA)
Topics
Cancer-Immunology
Cancer cell migration and the tumour microenvironment
Cell mechanics in cancer
Nanoagents for targeted cancer cell manipulation.
June 30, 2022
Speaker:
Cornelia Lee-Thedieck
Institute of Cell Biology and Biophysics, Leibniz University Hannover
Topics
Hematopoietic stem cells (HSCs) are the life-long source of all blood cells and, therefore, they are routinely applied to treat patients with hematological disorders. In vivo, HSCs are maintained in so-called stem cell niches. These highly specialized microenvironments regulate HSC behavior by an intricate network of signals provided by soluble factors, the extracellular matrix and neighboring niche cells. While the biochemical nature of the resulting interactions has been thoroughly studied during the last decades, only little attention has been paid to the role of biophysical signals in the niche. In this talk, I will shed light on the importance of biophysical parameters for controlling HSC behavior and how this knowledge can be applied in the development of cellular therapies and drug discovery.
Link:
Zoom-Link:
https://rwth.zoom.us/j/95826047675?pwd=dTl1Z0xHUzQxREszeTgvbGpDbUdGdz09
Meeting-ID: 958 2604 7675
Kenncode: 797721
Host:
Wolfgang Wagner
Helmholtz-Institute for Biomedical Engineering
Contact:
June 4-6, 2022
Speakers:
Joachim Heberle, Boris Musset, Ralph Graef, Thibaut Brunet, Steffen Lemke, Emmanuel Farge, Ulrich Schwarz, Ivan Radin, Frauke Graeter, Nicoletta Petridou
Topics
The mechanical properties of the extracellular environment play a crucial role for cell behaviour, development, and tissue organization. As a crucial step in evolution was the development of multicellular animals from unicellular organisms over 600 million years ago during this development, also the forces that cells need to deal with have changed. In this workshop we will elucidate different aspects of mechanobiology in relation to evolution. It will provide a stimulating forum with ample opportunities for oral and poster presentations, and plenty of possibilities to discuss and interact with colleagues, particularly between senior and junior colleagues.
Link:
Internationales Wissenschaftsforum Heidelberg
March, April, June, 2022
Topics
This ongoing talk series will feature world-leading speakers in science, technology and innovation. After each lecture, young scientists will have the chance to interview the speaker about more general questions (e.g. career choices, current issues, future trends) in a relaxed atmosphere during a Q&A session. Guests are highly welcome!
Link:
DWI Leibniz-Institut für Interaktive Materialien:
March 27-31, 2022
Topics
The 2022 edition of the Nanoengineering for Mechanobiology happens to be organised in a very peculiar period of our life, when science has played a central role in putting under some control the burden of COVID-19. We hope this event will be part of the process of finding our way through the situation, and it will bring to the little fishermen village of Camogli the same enthusiasm, passion and curiosity that we were used to see during the past editions, fostering the establishment of new and long-lasting collaborations.
January 27, 2022
Speaker:
Christian Bauckhage
Topics
The recent dramatic progress in artificial intelligence has mainly been driven by machine learning techniques. In this presentation, we will answer the questions: What is machine learning? How does it work? What do we have to consider when using machine learning? How can we apply it in practice, for instance in the context of medical research? We will look at the current state of the art in the field and try to predict potential future developments.
Link:
Zoom-Link:
https://rwth.zoom.us/j/91504326004?pwd=R2dvWEcyQmpCenNNZDRYWHMzVExLUT09
Meeting-ID: 915 0432 6004
Password: 334655
Host:
Rudolf Leube
Institute of Molecular and Cellular Anatomy (MOCA)
Contact:
