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December 17, 2020 |
Sven Ingebrandt: Transistor-based impedimetric monitoring of cell-substrate adhesion |
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Speaker |
Sven Ingebrandt |
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Professor in Molecular Science & Engineering Rheinisch-Westfälische Technische Hochschule Aachen Faculty of Electrical Engineering and Information Technology |
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Venue |
ZOOM-Session |
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Host |
Rudolf Leube DWI – Leibniz Institute for Interactive Materials |
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Contact |
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November 05, 2020 |
Pieter Hiemstra: Lung epithelial cell culture models for studying respiratory infections in times of COVID-19 |
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Speaker |
Pieter Hiemstra |
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Professor Pulmonology, in particular cell biology and immunology of pulmonary diseases https://www.universiteitleiden.nl/en/staffmembers/pi eter-hiemstra#tab-1 |
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Venue |
ZOOM-Session |
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October 15, 2020 |
David Mooney: Cells and Viscoelasticity |
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Speaker |
David Mooney |
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Robert P. Pinkas Family Professor of Bioengineering Harvard John A. Paulson School of Engineering and Applied Sciences |
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Venue |
ZOOM-Session |
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Host |
Laura De Laporte, Susan Babu |
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September 03, 2020 |
Xavier Trepat: Mechanobiology of epithelial folding and migration in intestinal organoids |
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Speaker |
Xavier Trepat |
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ICREA @ Institute for Bioengineering of Catalonia, Barcelona, Spain |
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Venue |
ZOOM-Session |
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July 10, 2020 |
Michael Sheetz: Out of Touch - Depletion of Mechanosensors Drives Wound-Healing and Cancer |
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Speaker |
Michael Sheetz |
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Welch Professor of Biochemistry Molecular MechanoMedicine Program Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX |
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Venue |
ZOOM-Session |
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June 25, 2020 |
Ben Fabry: Collective forces of organoids, tumoroids and tumor spheroids in 3-dimensional matrices |
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Speaker |
Ben Fabry |
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FAU Erlangen - Institut für Physik der Kondensierten Materie, Lehrstuhl für Biophysik |
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Venue |
ZOOM-Session |
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March 05, 2020 |
Ivan Bedzhov: Self-organization of the early mammalian embryo |
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Speaker |
Ivan Bedzhov |
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Embryonic Self-Organization Research Group Max Planck Institute for Molecular Biomedicine |
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Venue |
Großer Seminarraum, Uniklinikum, Pauwelsstraße 30, 52074 Aachen |
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Abstract |
After fertilization, the early embryo undergoes several rounds of divisions to form hollow-shaped blastocyst. The blastocyst contains pluripotent progenitors that will establish all the tissues of the fetus and multipotent stem cells that will give rise to the supportive extraembryonic tissues. The main function of the blastocyst is to initiate the process of implantation, which is a gateway for further development to term. However, the mammalian development at the time of implantation is largely unexplored as the maternal tissues completely engulf and conceal the embryo. Using the mouse as a model system, in combination with biomimetic platforms and embryonic stem cell techniques, we are trying to understand the process of self-organization of the embryonic tissues that dynamically acquire new shapes, functions and fates during the transition from pre- to post-implantation development. |
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March 03, 2020 |
Karsten Seidl: CMOS-based Micro and Nanosystems for Biomedical Applications |
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Speaker |
Karsten Seidl |
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Fraunhofer Institute for Microelectronic Circuits and Systems, FhG-IMS, Duisburg |
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Venue |
Walter-Schottky-Haus, Sommerfeldstraße 24, 52074 Aachen, Room 24 C 104 (Seminar room S1) |
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Abstract |
Karsten Seidl will talk about single-photon avalanche diodes (SPAD) for high-sensitive optical biosensors, nanoelectrodes for measuring intracellular potentials and pressure sensors for different biomedical applications. |
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February 20, 2020 |
Mike Boxem: Apical domain formation in C.elegans epithelia |
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Speaker |
Mike Boxem |
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Developmental Biology Utrecht University https://web.science.uu.nl/developmentalbiology/members/boxem.html |
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Venue |
Großer Seminarraum, Raum 38a, MTI I, Institute of Pharmacology and Toxicology, Wendlingweg 2, 52074 Aachen |
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February 06, 2020 |
Thomas M. Magin: Insights into mechanical and regulatory functions of epidermal keratins |
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Speaker |
Thomas M. Magin |
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Professor of Cell and Development Biology in the Institute of Biology, University of Leipzig |
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Venue |
Großer Seminarraum, Uniklinikum, Pauwelsstraße 30, 52074 Aachen |
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January 23, 2020 |
Carsten Bolm: Mechanochemistry: Is there a link to mechanobiology? |
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Speaker |
Carsten Bolm |
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Institute of Organic Chemistry RWTH Aachen University |
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Venue |
Großer Seminarraum, Uniklinikum, Pauwelsstraße 30, 52074 Aachen |
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January 09, 2020 |
Jan Lammerding: Squish and squeeze – Nuclear mechanics in physiology and disease |
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Speaker |
Jan Lammerding |
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Meinig School of Biomedical Engineering, Cornell University |
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Venue |
Großer Seminarraum, Uniklinikum, Pauwelsstraße 30, 52074 Aachen |
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Abstract |
The nucleus is the characteristic feature of eukaryotic cells and houses the genomic information of the cell. The Lammerding laboratory is combining cell and molecular biology approaches with tissue engineering and microfabrication techniques, live-cell microscopy, and in vivo models to investigate the interplay between nuclear structure, mechanics, and function. In particular, the research is addressing how physical forces acting on the nucleus, for example, in contracting muscle cells or during migration of cells through tight interstitial spaces, can challenge the integrity of the nucleus, alter its structure, and cause genomic and transcriptional changes. I will present recent findings that demonstrate the importance of nuclear mechanics during cell migration in confined environments in vitro and in vivo, as well as the functional consequences of cells having to squeeze their large nuclei through tight interstitial spaces and small pores in the extracellular matrix network. In addition, I will discuss recent findings that highlight the importance of the nuclear envelope proteins lamins A/C in mediating nuclear stability and mechanotransduction in mechanically stressed cells and tissues, including how lamin mutations result in reduced nuclear stability, increased nuclear damage in striated muscle cells, and DNA damage and activation of DNA damage response pathways, which may explain the tissue-specific defects in diseases caused by lamin mutations. Insights gained from these studies could improve prognostic approaches and motivate novel therapeutic approaches for these diseases. |
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