Topics:

A major challenge in the field of tissue engineering is the generation of new materials that can support angiogenesis, wherein endothelial cells from existing vasculature invade the surrounding matrix to form new blood vessels. To proceed, material design criteria based on natural tissue characteristics are needed, but currently lacking because we do not know how extracellular matrix (ECM) properties affect angiogenic sprouting and ultimately, blood vessel formation. Due to the complex nature of native ECMs, it is difficult to identify the role of individual matrix properties. Here, we have developed synthetic hydrogels with independently tunable properties, which are integrated into a microfluidic platform that mimics the process of angiogenesis in vitro.

In this talk, I will present our efforts to understand how matrix stiffness, adhesiveness and degradative properties jointly regulate angiogenic sprouting, and importantly, vascular lumen formation.

Speaker:

Britta Trappmann

Max Planck Institute for Molecular Biomedicine

http:/www.mpi-muenster.mpg.de/229627/trappmann

Link:

Zoom:

https://rwth.zoom.us/j/91504326004?pwd=R2dvWEcyQmpCenNNZDRYWHMzVExLUT09

Meeting-ID: 915 0432 6004

Kenncode: 334655

Host:

Rudolf Leube

Institute of Molecular and Cellular Anatomy (MOCA)

Contact:

me3t@ukaachen.de

Speaker:

Giorgio Scita

IFOM - the FIRC Institute of Molecular Oncology, Milan

Virtual tour:

Virtual Information Sessions: November 1+4, 2021

https://www.cornellbmephd.com/

Application:

https://gradschool.cornell.edu/admissions/apply/apply-now/

Speaker:

Giorgio Scita

IFOM - the FIRC Institute of Molecular Oncology, Milan

Link:

Zoom-Link:

https://rwth.zoom.us/j/91504326004?pwd=R2dvWEcyQmpCenNNZDRYWHMzVExLUT09

Meeting-ID: 915 0432 6004

Password: 334655

Host:

Jacopo Di Russo, Interdisciplinary Centre for Clinical Research (IZKF)

Contact:

me3t@ukaachen.de

Speakers:

Manu Prakash, Celeste Nelson, Ewa Paluch, Donald Ingber, Lisa Manning, Jochen Guck, A. James Hudspeth, Jennifer Lipincott-Schwartz, Prisca Liberali, Erwin Frey, Karen Alim, Julien vermot, Nicoletta Petridou, Stephen Grill, Michel Milinkovitch, Mustafa Khammash, Natalie Dye

Link:

Registration portal:

https://www.portal.graduatecenter.uni-muenchen.de/ocgc/qbm-symposium

Host:

Jacopo Di Russo, Interdisciplinary Centre for Clinical Research (IZKF)

Contact:

me3t@ukaachen.de

Speaker:

Jörg Höhfeld, Dietmar Manstein, Ivan Dikic, Terje Johansen, Dieter O. Fürst, Michael Hesse, Carsten Grashoff, Matthias Rief, Bernd Hoffmann, Wolfgang Linke, David Vilchez, F.-Ulrich Hartl, Bernd Bukau, Wojciech Pokrzywa, Marcus Krüger, Pitter F. Huesgen, Christian Behrends, Markus Rinschen, Elke Deuerling, Deborah Trentini Schmidt, David Balchin, Johannes Buchner, Simon Alberti, Sebastian Gehlert, Mathias Gautel, Bettina Warscheid, Maja Köhn, Sara Wickström, Britta Trappmann, Carien Niessen, Lydia Sorokin, Waldemar Kolanus, Lea Sistonen,

Link:

For more information please visit:

https://www.moca.rwth-aachen.de/euroif2021

Topics:

Cells of multicellular organisms are constantly exposed to stress resulting from mechanical forces. The research unit FOR 2743 'Mechanical Stress Protection' (www.for2743.uni-bonn.de) investigates proteostasis mechanisms essential for maintaining the mechanically stressed proteome.

The first international conference of the research unit provides a platform for the integration of mechanobiology and proteostasis. It brings together scientists of both research areas to promote the exchange of data, concepts, and ideas and to foster collaborative efforts.

On behalf of all members of the research unit I would like to welcome you. I hope you will enjoy our conference.

Jörg Höhfeld

Venue:

Leipzig

General Information:

https://conference.uni-leipzig.de/poc/2021/?page=general

Speakers:

Confirmed Speakers (in alphabetical order):

Richard Barr (USA), Otger Campàs (USA, Germany), Ovijit Chaudhuri (USA), Marvin Doyley (USA), Elisabeth Fischer-Friedrich (Germany), Jing Guo (Germany), Ming Guo (USA), John Huston III (USA), Johanna Ivaska (Finland), Paul Janmey (USA), Sarah Köster (Germany), Franziska Lautenschläger (Germany), Malgorzaka Lekka (Poland), Matthias Lütolf (Switzerland), Yanlan Mao (Great Britain), Andreas Melzer (Germany), Cornelia Monzel (Germany), Lance Munn (USA), Xavier Trepat (Spain), Jens Würfel (Switzerland), Liang Zhu (China)

PoC Organizing Committee:

Josef A. Käs (Germany), Ingolf Sack (Germany), Harald Herrmann (Germany), Ben Fabry (Germany), Elisabeth Fischer-Friedrich (Germany), Thomas Fuhs (Germany)

Contact:

poc@uni-leipzig.de

About:

We are excited to share that registration and abstract submission for ‘Multiscale Mechanochemistry & Mechanobiology’ is now open.

Dear colleague,

we are excited to share that registration and abstract submission for ‘Multiscale Mechanochemistry & Mechanobiology’ is now open.

As announced earlier this year, the conference will be a virtual event, hosted on Webex. Registration is free of charge, but required.

Approximately 25 slots are available for contributed talks (15 min incl. questions). In addition, we are planning two poster sessions on Gather.town.

Oral presentation abstract deadline: June 30, 2021

Poster presentation abstract deadline: Aug 15, 2021

Abstracts can be submitted by email, following the guidelines on the website.

We are looking forward to see many of you at the end of August.

Best wishes,

Kerstin Blank and Matt Harrington

Für Presserückfragen wenden Sie sich bitte an:

Uniklinik RWTH Aachen

Stabsstelle Unternehmenskommunikation

Dr. Mathias Brandstädter

Tel. 0241 80-89893

kommunikation@ukaachende

Venue:

Webex

We are excited to share that registration and abstract submission for ‘Multiscale Mechanochemistry & Mechanobiology’ is now open.

As announced earlier this year, the conference will be a virtual event, hosted on Webex. Registration is free of charge, but required.

Approximately 25 slots are available for contributed talks (15 min incl. questions). In addition, we are planning two poster sessions on Gather.town.

Oral presentation abstract deadline:

June 30, 2021

Poster presentation abstract deadline:

August 15, 2021

Abstracts can be submitted by email, following the guidelines on the website.

We are looking forward to see many of you at the end of August.

Best wishes,

Kerstin Blank and Matt Harrin

Intro to Computational Modeling & Python:

August 1st, 2021 (Sunday)

Summer School:

August 2nd – 6th, 2021 (Monday – Friday)

Model-Building Hackathon:

August 7th – 8th, 2021 (Saturday / Sunday)

Background:

Mechanistic modeling is an integral part of contemporary bioscience, used for hypothesis generation and testing, experiment design and interpretation, and the design of therapeutic interventions. The CompuCell3D modeling environment allow researchers with modest programing experience to rapidly build and execute complex Virtual Tissue simulations. With CompuCell3D you can simulate biology from the subcellular scale to the tissue scale. For instance, you can model tumor growth, what happens to tissues and cells when exposed to toxic compounds, viral spread in tissues, early embryonic development, intra- and extra-cellular biochemical networks, and more. CompuCell3D natively supports SBML and MaBoSS model integration. Try out models without any installation.

For more information please visit:

www.compucell3d.org

Venue:

Maastricht, The Netherlands

Lorenzo Moroni - Chair (Maastricht University)

Liesbet Geris - co-chair (University of Liege)

Stefan Jockenhövel - co-chair (RWTH Aachen)

Learn about our
conference

https://www.termis.org

Speaker:

Benoit Ladoux

Université de Paris & CNRS

Institute Jacques Monod

ZOOM-Session:

https://rwth.zoom.us/j/99418690091?pwd=S 2E5emJVN1U1R0p6ZlNIcFhOc3NlZz09

Meeting-ID:

994 1869 0091

Passwort:

066958

Host:

Rudolf Leube

Institute of Molecular and Cellular Anatomy (MOCA)

Contact:

rleube@ukaachen.de

Abstract:

Active Nematic Behaviors of Cellular Monolayers

I will present how active nematic activity of cellular monolayers can help to understand biological processes and tissue organization.

In the first part, I will show how these active behaviors and stresses govern cell extrusion. By modelling the epithelium as an active nematic liquid crystal and measuring mechanical parameters such as strain rates and stresses measurements within cellular monolayers, I will show that apoptotic cell extrusion is provoked by singularities in cell alignments in the form of comet-shaped topological defects. These results highlight the importance of active nematic nature of epithelia.

In the second part, I will focus on the intriguing extensile behavior of epithelial cells as a collective when single cells behave as contractile systems. Through a combination of experiments and in silico modelling, we uncover the mechanism behind this switch of behavior of cell monolayers from extensile to contractile as the weakening of intercellular contacts. We find that this switch in active behavior also promotes the buildup of tension at the cell-substrate interface through an increase in actin stress fibers and higher traction forces. Such differences in extensility and contractility act to sort cells, thus determining a general mechanism for mechanobiological pattern formation.

Dear Colleague,

We are delighted to inform you that the 3rd Conference on Multiscale Mechanochemistry and Mechanobiology will take place online and will be free of charge. Considering the still rather unpredictable development of the pandemic, we believe that this is the best option to keep everyone safe. We are planning with a large number contributed talks and posters and hope to see many old and new faces at what we expect to be a very exciting meeting. Please check here for details about the conference topics as well as updates on abstract submission.

As a primer for the conference, we are starting a Virtual Seminar Series with events every 5-6 weeks. Our first seminar will take place on Monday, Feb 15, 2021 at 15 CET (see below for details). We have a great line-up of speakers with contributions from Jeffrey Moore, Hai Qian and Yun Liu as well as Kris Dahl and Antoine Deblais. Registration is free, but required.

Last but not least, we are excited to announce the first Gordon Research Conference on Multiscale Mechanochemistry and Mechanobiology, which will take place in Ventura in the summer of 2022.

We hope to see many of you soon, either virtual in 2021 or in person in 2022!

Best wishes,

Matt Harrington and Kerstin Blank

Speaker:

Paul Steinmann and Silvia Budday

Institute of Applied Mechanics

Friedrich-Alexander University Erlangen-Nürnberg

ZOOM-Session:

https://rwth.zoom.us/j/91373023958?pwd=NGdab3FkUE9QaTFTb2dnejZUeWJaUT09

Passwort:

483892

Host:

Ana-Suncana Smith

PULS Group, Institute for Theoretical Physics, FAU Erlangen

Contact:

smith@physik.fau.de

Speaker:

Sirio Dupont

Department of Molecular Medicine, University of Padua

ZOOM-Session:

https://rwth.zoom.us/j/99154594806?pwd=elJwd1h0ZGxOY1NUR29qUnhCNzFhZz09

Meeting-ID:

991 5459 4806

Passwort:

848470

Host:

Mohamed Mabrouk

Helmholtz-Institute for Biomedical Engineering,

Division of Stem Cell Biology and Cellular Engineering

Contact:

me3t@ukaachen.de

Venue:

Aachen/Rolduc

Topics:

• Intermediate filaments during development and differentiation

• 3D organization of intermediate filaments:Facilitators of cell and tissue morphology and function

• Intermediate filaments as stress protectors

• Intermediate filaments as disease modulators

• Latest developments and upcoming challenges

Background:

The Organizing Committee cordially invites you to attend the European Meeting on Intermediate Filaments. The meeting is also organized by RWTH Aachen University and will be held in beautiful Rolduc. The conference continues a series of intimate get-togethers uniting the intermediate filament community. The conferences are held every two years in Europe. Attendance of young researchers is strongly encouraged. Given the recent cancellation of multiple international meetings such as the Gordon Research Conference on Intermediate Filaments, we extend our especially warm welcome to participants from all over the world.

We are very excited about the impressive roster of distinguished speakers who already agreed to contribute. To enable intense exchange between all participants, we have set aside additional time for more than 20 talks and 24 flash talks that will be selected from the submitted abstracts.

Speakers:

Mike Boxem, John T.  Connelly, Pierre Coulombe, Dennis Discher, John Eriksson, Sandrine Etienne-Manneville, Roland Foisner, Kathleen Green, Harald Herrmann, Elly Hol, Sarah Köster, Michel Labouesse, Jan Lammerding, Ohad Medalia, Isabelle Migeotte, Nicolas Plachta, Arnoud Sonnenberg, Didier Stainier, Sergei Strelkov

For more information please visit: 

https://www.moca.rwth-aachen.de/euroif2021

Speaker:

Jörg Höhfeld, Dietmar Manstein, Ivan Dikic, Terje Johansen, Dieter O. Fürst, Michael Hesse, Carsten Grashoff, Matthias Rief, Bernd Hoffmann, Wolfgang Linke, David Vilchez, F.-Ulrich Hartl, Bernd Bukau, Wojciech Pokrzywa, Marcus Krüger, Pitter F. Huesgen, Christian Behrends, Markus Rinschen, Elke Deuerling, Deborah Trentini Schmidt, David Balchin, Johannes Buchner, Simon Alberti, Sebastian Gehlert, Mathias Gautel, Bettina Warscheid, Maja Köhn, Sara Wickström, Britta Trappmann, Carien Niessen, Lydia Sorokin, Waldemar Kolanus, Lea Sistonen,

Links:

Zoom:

https://harvard.zoom.us/j/98697276353?pwd=STlzRmp2ZUJuUkpQbW9QQ1pxdzdGUT09

YouTube Live:

here

Twitter: @CellMigration

Website and registration: www.cellmigrationseminars.com

YouTube Archive of past talks:

https://www.youtube.com/channel/UCQI0OwJIn8TdvM0_z_HCLrw/videos

Topics:

Dear cell migration fans,

We're back! Cell Migration Seminars returns on October 5, 2021, for nine sessions. See below for the schedule. We will continue to archive as many talks as possible on our YouTube page, but we encourage you to tune in live to engage with the speakers and provide the energy to keep this series going.

As in previous seasons, we will meet weekly on Tuesdays at 11am ET (8am Pacific, 4pm BST, 5pm CET, 8:30pm IST, 1am AEST).

Please feel free to forward this email to any colleagues who might be interested and encourage them to sign up for the mailing list. 

Thanks to the Company of Biologists for their support.

Best wishes,

The Cell Migration Seminars team