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Actuation of Soft Thermoresponsive Hydrogels Mechanically Stimulates Osteogenesis in Human Mesenchymal Stem Cells without Biochemical Factors
Castro Nava A, Doolaar IC, Labude-Weber N, Malyaran H, Babu S, Chandorkar Y, Di Russo J, Neuss S, De Laporte L
Capturing the mechanosensitivity of cell proliferation in models of epithelium
Höllring K, Nuić L, Rogić L, Kaliman S, Gehrer S, Rehfeldt F, Hubert M, Smith AS
movies |
pumed |
Morphology as indicator of adaptive changes of model tissues in osmotically and chemically changing environments
Höllring K, Vurnek D, Gehrer S, Dudziak D, Hubert M, Smith AS
Anisotropic molecular diffusion in confinement II: A model for structurally complex particles applied to transport in thin ionic liquid films
Höllring K, Baer A, Vučemilović-Alagić N, Smith DM, Smith AS
movies |
pubmed |
Anisotropic molecular diffusion in confinement I: Transport of small particles in potential and density gradients
Höllring K, Baer A, Vučemilović-Alagić N, Smith DM, Smith AS
Plasticity of cytoplasmic intermediate filament architecture determines cellular functions
Schwarz N and Leube RE
movies |
pubmed |
Epigenetic biomarkers to track differentiation of pluripotent stem cells
Schmidt M, Zeevaert K, Elsafi Mabrouk MH, Goetzke R, Wagner W
Smuggling on the Nanoscale—Fusogenic Liposomes Enable Efficient RNA-Transfer with Negligible Immune Response In Vitro and In Vivo
Hoffmann M, Gerlach S, Takamiya M, Tarazi S, Hersch N, Csiszár A, Springer R, Dreissen G, Scharr H, Rastegar S, Beil T, Strähle U, Merkel R and Hoffmann B
Wall shear stress during impingement at the building platform can exceed nozzle wall shear stress in microvalve-based bioprinting
Nasehi R, Aveic S, Fischer H
3D geometry orchestrates the transcriptional landscape of metastatic neuroblastoma cells in a multicellular in vitro bone model
Nasehi R, Abdallah AT, Pantile M, Zanon C, Vogt M, Rütten S, Fischer H, Aveic S
A Fibrin-Based Human Multicellular Gingival 3d Model Provides Biomimicry and Enables Long-Term In Vitro Studies
Sahle M, Wachendörfer M, Palkowitz AL, Nasehi R, Aveic S, Fischer H
Varying the stiffness and diffusivity of rod-shaped microgels independently through their molecular building blocks
Kittel Y, Guerzoni LPB, Itzin C, Rommel D, Mork M, Bastard C, Häßel B, Omidinia-Anarkoli A, Centeno SP, Haraszti T, Kim K, Guck J, Kuehne AJC, De Laporte L
Actuation of soft thermoresponsive hydrogels mechanically stimulates osteogenesis in human mesenchymal stem cells
without biochemical factors
Castro Nava A, Doolaar IC, Labude N, Malyaran H, Babu S, Chandorkar Y, Di Russo J, Neuss S, De Laporte L
movies |
pubmed |
Analysis of flow‑induced transcriptional response and cell alignment of different sources of endothelial cells used in
vascular tissue engineering
Rojas‑González DM, Babendreyer A, Ludwig A and Mela P
A keratin code defines the textile nature of epithelial tissue architecture
Di Russo J, Magin TM and Leube RE
Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release
Grannemann C, Pabst A, Honert A, Schieren J, Martin C, Hank S, Böll S, Bläsius K, Düsterhöft S, Jahr H, Merkel R, Leube RE, Babendreyer A, Ludwig A
movies |
pubmed |
Transformative Medical Materials
De Laporte L, Kiessling F
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pubmed |
Transformative materials to create 3D functional human tissue models in vitro in a reproducible manner
Gerardo-Nava JL, Jansen J, Günther D, Klasen L, Thiebes AL, Niessig B, Bergerbit C, Meyer AA, Linkhorst J, Bart M, Akhyari P, Stingl J, Nagel S, Stiehl T, Lampert A, Leube RE, Wessling M, Santoro F, Ingebrandt S, Jockenhoevel S, Herrmann A, Fischer H, Wagner W, Schmitt RH, Kiessling F, Kramann R, De Laporte L
Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology
Fernández-Colino A, Kiessling F, Slabu I, De Laporte L, Akhyari P, Nagel SK, Stingl J, Reese S, Jockenhoevel S
movies |
pubmed |
Towards the Next Generation of Neural Iontronic Interfaces
Forró C, Musall S, Montes VR, Linkhorst J, Walter P, Wessling M, Offenhäuser A, Ingebrandt S, Weber Y, Lampert A, Santoro A
movies |
pubmed |
Polarity signaling balances epithelial contractility and mechanical resistance
Rübsam M, Püllen R, Tellkamp F, Bianco A, Peskoller M, Bloch W, Green KJ, Merkel R, Hoffmann B, Wickström SA, Niessen CM
Elastomeric Pillar Cages Modulate Actomyosin Contractility of Epithelial Microtissues by Substrate Stiffness and Topography
Esser L, Springer R, Dreissen G, Lövenich L, Konrad J, Hampe N, Merkel R, Hoffmann B, Noetzel E
movies |
pubmed |
YAP1 is essential for self-organized differentiation of pluripotent stem cells
Zeevaert K, Goetzke R, Elsafi Mabrouk MH, Schmidt M, Maaßen C, Hennecke A, He C, Gillner A, Zenke M, Wagner W
Bioprinting-associated pulsatile hydrostatic pressure elicits a mild proinflammatory response in epi- and endothelial cells
Nasehi R, Schieren J, Grannemann C, Palkowitz AL, Babendreyer A, Schwarz N, Aveic S, Ludwig A, Leube RE, Fischer H
movies |
pubmed |
Mechanobiological implications of age-related remodelling in the outer retina
Piskova T, Kozyrina AN, Di Russo J
movies |
pumed |
The wetware credentials of intermediate filaments involves coordinating, organising and networking in cells and tissues
Leube RE, Quinlan RA
movies |
pumed |
Intermediate Filaments - Encyclopedia of Cell Biology
Leube RE. and Schwarz Nicole
movies |
pumed |
movies |
pubmed |
Intrinsic cell rheology drives junction maturation
Sri-Ranjan K, Sanchez-Alonso JL, Swiatlowska P, Rothery S, Novak P, Gerlach S, Koeninger D, Hoffmann B, Merkel R, Stevens MM, Sun SX, Gorelik J, Braga VMM
Regionally specific levels and patterns of keratin 8 expression in the mouse embryo visceral endoderm emerge upon anterior-posterior axis determination
Despin-Guitard E, Quenec’Hdu R, Nahaboo W, Schwarz N, Leube RE, Chazaud C and Migeotte I
Pre-Programmed Rod-Shaped Microgels to Create Multi-Directional Anisogels for 3D Tissue Engineering
Braunmiller DL, Babu S, Gehlen DB, Seuß M, Haraszti T, Falkenstein A, Eigen J, De Laporte L, Crassous JJ
movies |
pubmed |
Cortical tension regulates desmosomal morphogenesis
Moch M, Schieren J and Leube RE
A Ca2+-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics
Ratajczyk S, Drexler C, Windoffer R, Leube RE and Fuchs P
Bioprinting-Associated Shear Stress and Hydrostatic Pressure Affect the Angiogenic Potential of Human Umbilical Vein Endothelial Cells
Köpf M, Nasehi R, Kreimendahl F, Jockenhoevel S, Fischer H
movies |
pubmed |
First-Principle Coarse-Graining Framework for Scale-Free Bell-Like Association and Dissociation Rates in Thermal and Active Systems
Janeš JA, Monzel C, Schmidt D, Merkel R, Seifert U, Sengupta K and Smith AS
movies |
pubmed |
ECM-transmitted shear stress induces apoptotic cell extrusion in early breast gland development
Friedland F, Babu S, Springer R, Konrad J, Herfs Y, Gerlach S, Gehlen J, Krause HJ, De Laporte L, Merkel R, Noetzel E
movies |
pubmed |
How do the Local Physical, Biochemical, and Mechanical Properties of an Injectable Synthetic Anisotropic Hydrogel Affect Oriented Nerve Growth?
Babu S, Chen I, Vedaraman S, Gerardo-Nava J, Licht C, Kittel Y, Haraszti T, Di Russo J and De Laporte L
movies |
pubmed |
Characterization of transient rheological behavior of soft materials using ferrofluid droplets
Azarkh A, Geiger M, Jung SH, Noetzel E, Merkel R, Pich A, Schnakenberg U
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pubmed |
Cells feel the beat – temporal effect of cyclic mechanical actuation on muscle cells
Chandorkar Y, Bastard C, Di Russo J, Haraszt T, De Laporte L
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pubmed |
Combining Image Restoration and Traction Force Microscopy to Study Extracellular Matrix-Dependent Keratin Filament Network Plasticity
Yoon S, Windoffer R, Kozyrina AN, Piskova T, Di Russo J and Leube RE
movies |
pubmed |
Quantitative mapping of keratin networks in 3D commentary
Windoffer R, Schwarz N, Yoon S, Piskova T, Scholkemper M, Stegmaier J, Bönsch A, Di Russo J, Leube RE
Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo
Nahaboo W , Eski SE , Despin-Guitard E, Vermeersch M, Versaevel M , Saykali B, Monteyne D, Gabriele S, Magin TM, Schwarz N , Leube RE, Zwijsen A, Perez-Morga D, Singh SP, Migeotte I
The spatial self-organization within pluripotent stem cell colonies is continued in detaching aggregates
Mabrouk MHE, Goetzke R, Abagnale G, Yesilyurt B, Salz L, Cypris O, Glück P, Liesenfelder S, Zeevaert K, Ma Z, Toledo MAS, Li R, Costa IG,
Lampert A, Pachauri V, Schnakenberg U, Zenke M, Wagner W
An exact algorithm to detect the percolation transition in molecular dynamics simulations of cross-linking polymer networks
Livraghi M, Höllring K, Wick CR, Smith DM and Smith A-S
Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics
Jain P, Nishiguchi A, Linz G, Wessling M, Ludwig A, Rossaint R, Möller M, Singh S
Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity
Di Russo J, Young JL, Wegner JWR, Steins T, Kessler H, Spatz JP
Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe
Israel MR , Dash TS, Bothe SN, Robinson SD, Deuis JR, Craik DJ, Lampert A, Vetter I and Durek T
Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity
Cann KL, Meents JE, Eswaran VSB, Dohrn MF, Bott R, Maier A, Bialer M, Hautvast P, Erickson A, Rolke R, Rothermel M, Körner J, Kurth I, Lampert A
Assessing the impact of pain-linked Nav1.7 variants: An example of two variants with no biophysical effect
Hoffmann M, Hersch N, Gerlach S, Dreissen G, Springer R, Merkel R, Csiszár A and Hoffmann B
Growth, lifetime, directional movement and myosin‑dependent motility of mutant keratin granules in cultured cells
Lehmann SM, Leube RE, Windoffer R
Mechanism underlying hooked resurgent-like tail currents induced by an insecticide in human cardiac Nav1.5
Thull S, Neacsu C, O'Reilly AO, Bothe S, Hausmann R, Huth T, Meents J, Lampert A
Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine
Lampert A, Bennett DL, McDermott LA, Neureiter A, Eberhardt E, Winner B, Zenke M
Stretchable electrical cell-substrate impedance sensor platform for monitoring cell monolayers under strain
Zhou C, Bette S, Babendreyer A, Hoffmann C, Gerlach S, Kremers T, Ludwig A, Hoffmann B, Merkel R, Uhlig S, Schnakenberg U
movies |
pubmed |
Mechanical Regulation of Epithelial Tissue Homeostasis
Kaliman S, Hubert M, Wollnik C, Nuić L, Vurnek D, Gehrer S, Lovrić J, Dudziak D, Rehfeldt F and Smith AS
movies |
pubmed |
Complex Size and Surface Charge Determine Nucleic Acid Transfer by Fusogenic Liposomes
Hoffmann M, Hersch N, Gerlach S, Dreissen G, Springer R, Merkel R, Csiszár A and Hoffmann B
Controlling Structure with Injectable Biomaterials to Better Mimic Tissue Heterogeneity and Anisotropy
Babu S, Albertino F, Anarkoli AO and De Laporte L
From Microspikes to Stress Fibers: Actin Remodeling in Breast Acini Drives Myosin II-Mediated Basement Membrane Invasion
Eschenbruch J, Dreissen G, Springer R, Konrad J, Merkel R, Hoffmann B and Noetzel E
How Mechanical Forces Change the Human Endometrium during the Menstrual Cycle in Preparation for Embryo Implantation
Sternberg AK, Buck VU, Classen-Linke I and Leube RE
Skin under Strain: From Epithelial Model Tissues to Adult Epithelia
Püllen R, Konrad J, Merkel R and Hoffmann B
Multiscale 3D Bioprinting by Nozzle-Free Acoustic Droplet Ejection
Jentsch S, Nasehi R, Kuckelkorn C, Gundert B, Aveic S and Fischer H
movies |
pubmed |
Hemidesmosome-Related Keratin Filament Bundling and Nucleation
Moch M and Leube RE
Steroid hormones and human choriogonadotropin influence the distribution of alpha6-integrin and desmoplakin 1 in gland-like endometrial epithelial spheroids
Buck VU, Kohlen MT, Sternberg AK, Rösing B, Neulen J , Leube RE, Classen-Linke I
Cell Force-Driven Basement Membrane Disruption Fuels EGF- and Stiffness-Induced Invasive Cell Dissemination from Benign Breast Gland Acini
Gaiko-Shcherbak A, Eschenbruch J, Kronenberg NM, Teske M, Wolters B, Springer R, Gather MC, Merkel R, Hoffmann B, Noetzel E
movies |
pubmed |
Digitally Fabricated and Naturally Augmented In Vitro Tissues
Duarte Campos DF and De Laporte L
Senescence-Associated Metabolomic Phenotype in Primary and iPSC-Derived Mesenchymal Stromal Cells
Fernandez-Rebollo E, Franzen J, Goetzke R, Hollmann J, Ostrowska A, Oliverio M, Sieben T, Rath B, Kornfeld JW, Wagner W
PRDM8 reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation
Cypris O, Eipel M, Franzen J, Rösseler C, Tharmapalan V, Kuo CC, Vieri M, Nikolić M, Kirschner M, Brümmendorf TH, Zenke M, Lampert A, Beier F, Wagner W
Regulation of keratin network dynamics by the mechanical properties of the environment in migrating cells
Pora A, Yoon S, Dreissen G, Hoffmann B, Merkel R, Windoffer R and Leube RE
Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells
Babendreyer A, Rojas-Gonzalez DM, Giese AA, Fellendorf S, Düsterhöft S, Mela P and Ludwig A
movies |
pubmed |
Mechanobiology of Epithelia: From the Perspective of Extracellular Matrix Heterogeneity
Kozyrina AN, Piskova T and Di Russo J
Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes
Bornes L, Windoffer R, Leube RE, Morgner J, van Rheenen J
movies |
pubmed |
Cell Mechanics in Embryoid Bodies
Zeevaert K, Elsafi Mabrouk MH, Wagner W and Goetzke R
Model for Bundling of Keratin Intermediate Filaments
Haimov E, Windoffer R, Leube RE, Urbakh M, Kozlov M
Choosing the Right Differentiation Medium to Develop Mucociliary Phenotype of Primary Nasal Epithelial Cells In Vitro
AE Luengen, C Kniebs, EM Buhl, CG Cornelissen, T Schmitz-Rode, S Jockenhoevel, AL Thiebes
Genetic barcoding reveals clonal dominance in iPSC-derived mesenchymal stromal cells
Hollmann J, Brecht J, Goetzke R, Franzen J, Selich A, Schmidt M, Eipel M, Ostrowska A, Hapala J, Fernandez-Rebollo E, Müller-Newen G, Rothe M, Eggermann T, Zenke M and Wagner W
Different Frequency of Cyclic Tensile Strain Relates to Anabolic/Catabolic Conditions Consistent with Immunohistochemical Staining Intensity in Tenocytes
Kubo Y, Hoffmann B, Goltz K, Schnakenberg U, Jahr H, Merkel R, Schulze‐Tanzil G, Pufe T and Tohidnezhad M
Why do epithelia display heterogeneity? Bridging physical and biological concepts
Vishwakarma M and Di Russo J
Cellular responses to beating hydrogels to investigate mechanotransduction
Chandorkar Y, Castro Nava A, Schweizerhof S, Van Dongen M, Haraszti T, Köhler J, Zhang H, Windoffer R, Mourran A, Möller M, De Laporte L
Keratin intermediate filaments: intermediaries of epithelial cell migration
Yoon S, Leube RE
β1 and β3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5
Maroni M, Körner J, Schüttler J, Winner B, Lampert A, Eberhardt E
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pubmed |
Differentiation of Induced Pluripotent Stem Cells towards Mesenchymal Stromal Cells is Hampered by Culture in 3D Hydrogels
Goetzke R, Keijdener H, Franzen J, Ostrowska A, Nüchtern S, Mela P and Wagner W
