Mechanobiology of differentiation and invasion in 3D cell assemblies

Projects

Mechanostimulation to direct differentiation of iPSCs and iPSC-derived embryoid bodies

Helmholtz-Institute for Biomedical Engineering, Division of Stem Cell Biology

Breast gland development and cell invasion in strained microenvironments

Institute of Biological Information Processing (IBI-2): Mechanobiology, Forschungszentrum Jülich

Mechanobiology of human embryo implantation

Institute of Molecular and Cellular Anatomy (MOCA), Uniklinik RWTH Aachen

Toward quantitative modeling and simulations of structure formation in epithelium – relating tissue topology and homeostasis

PULS Group, Institute for Theoretical Physics, FAU Erlangen

Mechanophysiology and -pathology of multilayer epithelia

Projects

3D-mapping of epidermal tissue mechanobiology during growth and upon wounding

Helmholtz-Institute for Biomedical Engineering, Division of Stem Cell Biology

Consequences of keratin mutations on epidermal tissue mechanics and mechanoresponses

Institute of Molecular and Cellular Anatomy (MOCA), Uniklinik RWTH Aachen

Mechanical triggers in painful skin diseases

Institute of Neurophysiology, Uniklinik RWTH Aachen

Role of ion channels and ADAM-family metalloproteinases in mechanobiology

Institute of Molecular Pharmacology, Division of Pharmacology in Inflammation, Uniklinik RWTH Aachen

Mechanobiological cross-talk between epithelia and their immediate environment

Projects

Interaction of the alveolar epithelium and macrophages under mechanical strain

Institute of Pharmacology and Toxicology, Uniklinik RWTH Aachen

Modeling the small airway mucosa in vitro to study mechanobiological effects on tissue remodeling

Department of Biohybrid & Medical Textiles (BioTex), AME-Institute of Applied Medical Engineering, RWTH Aachen University

Mechanical triggers in painful skin diseases

Interdisciplinary Centre for Clinical Research (IZKF), RWTH Aachen University Hospital
Institute of Molecular and Cellular Anatomy (MOCA), Uniklinik RWTH Aachen

Biofabrication techniques to analyze and steer mechanobiology of epithelia

Projects

Pre-programming anisometric microgels to orthogonally study the effect of mechanical signals on epithelia in 3D tissue models

DWI - Leibniz Institute for Interactive Materials

Mechanobiological challenges related to hydrogel-based bioprinting technology for manufacturing novel 3D cell culture models

Department of Dental Materials and Biomaterials Research (ZWBF), Uniklinik RWTH Aachen

Development of light-driven deformable and electroactive 3D scaffolds for electromechanical modulation of epidermal tissues

Neuroelectronic Interfaces, RWTH Aachen University

ME3T - Mechanobiology in Epithelial 3D Tissue Constructs

Contact

Prof. Dr. med. Rudolf Leube
Spokesperson

Prof. Dr.-Ing. Laura De Laporte
Vice Spokesperson

Prof. Dr. rer. nat. Rudolf Merkel
VIce Spokesperson

Dr. rer.nat. Marcin Moch
Coordinator

Institute of Molecular and Cellular Anatomy (MOCA)
Uniklinik RWTH Aachen
Wendlingweg 2
52074 Aachen

Phone: +49 241 80 89107
me3t@ukaachen.de

Team

Doctoral Researchers

Scientific Support

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Mercator Fellows

All about ME3T

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Projects

Mechanobiology of differentiation and invasion in 3D cell assemblies

Mechanophysiology and -pathology of multilayer epithelia

Mechanobiological cross-talk between epithelia and their immediate environment

Biofabrication techniques to analyze and steer mechanobiology of epithelia

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