Mechanobiology in Epithelial
3D Tissue Constructs


Department Department of Dental Materials and Biomaterials Research (ZWBF)
Job site: RWTH Aachen University Hospital
Description of the position: Biomedical Engineer, Mechanical Engineer: Mechanobiological challenges related to hydrogel-based bioprinting technology for manufacturing novel 3D cell culture models
Job description: Our profile
The Dental Materials and Biomaterials Research team de-velops tailored biomaterials with tissue engineering tech-niques. It focuses on novel 3D bioprinting techniques to manufacture biomimetic 3D in vitro models and tissue re-placements for in vivo applications. Scientists from different disciplines work together to tackle the associated interdisci-plinary challenges.

Your tasks
You will be part of the DFG-funded graduate school Mechanobiology in Epithelial 3D Tissue Constructs (MEƎT; https://me3t.rwth-aachen.de/). In project D2 'Mechano-biological challenges related to hydrogel-based bioprinting technology for manufacturing novel 3D cell culture models' you will employ our different custom-made 3D bioprinting platforms and our self-constructed bioreactors. You will investigate cellular responses to the printing-related shear stress and hydrostatic pressure (mechanical signals). You will compare different bioprinting techniques, different process parameters, use a variety of natural and synthetic hydrogels and hydrogel blends, and test the effects of cell density. The shear stress and hydrostatic pressure that occur during the printing process are investigated by finite element fluid dynamic models. The mechanical signals are then be correlated with the observed cellular responses. The successful applicant must be accepted as a Dr.-Ing. candidate at RWTH Aachen University.
Requirements / Your profile: You have quickly and very successfully completed your Master studies at a university (Biomedical Engineering, Materials Science, Mechanical Engineering with focus on Biomedical Technique, or comparable study programs). You intend to obtain a doctorate (Dr.-Ing.) on a challenging transdisciplinary topic.
During your studies you have acquired knowledge in the transdisciplinary fields of biomaterials, tissue engineering, and cell biology. Moreover, you have comprehensive knowledge in fluid mechanics. Beside your scientific qualification you distinguish yourself by single-mindedness and resilience and by an excellent capacity for teamwork. You are fluent in written and spoken English.
Pay category: TV-L 13 (100%)
Hiring date: July 01, 2022
Duration of employment: 3 years
Contact: Univ.-Prof. Dr.-Ing. Horst Fischer
Email: hfischer@ukaachen.de, phone: +49 (0)241 80-80935
www.biomaterials-research.de

Equal career prospects for women and men.
Severely disabled applicants with equal qualification will be given preferential consideration.
Application deadline: March 31, 2022