Mechanobiology in Epithelial
3D Tissue Constructs
Department Institute of Molecular and Cellular Anatomy (MOCA)
Job site: RWTH Aachen University Hospital
Description of the position: PhD Position: Epidermal Tissue Stability in Keratinopathy
Job description: Our profile
Research at MOCA deals with the cytoskeleton as a main integrator of cell and tissue function. Particular emphasis is on the use of morphological and functional imaging techniques in vital cells, tissues and organisms (

Your tasks
You will be part of the DFG-funded graduate school "Mechanobiology in Epithelial 3D Tissue Constructs" (MEŽT; You are expected to work in an interdisciplinary team with a keen interest in novel technological developments. Your project B2 "Consequences of disease-causing cytoskeletal mutations on epidermal tissue stability" combines 3D culture systems with state-of-the-art microscopy and mechanobiological analyses. You will monitor cytoskeletal keratin network dynamics, measure local mechanical properties and study mechanoresponses in wild-type and mutant keratinocytes grown as monolayers and epidermal equivalents.
Requirements / Your profile: We are looking for a highly motivated and ambitious PhD student with a strong background in cell biology or mechanobiology. Knowledge in the fields of biomaterials, tissue engineering and microscopy is appreciated but no prerequisite. The successful applicant must have completed a master or equivalent degree in biology, biomedical engineering or a comparable study program to be accepted either as a Dr. rer. nat. or Dr. rer. medic. candidate at RWTH Aachen University. Willingness for teamwork, the ability to work independently and excellent English language skills are expected.
Pay category: TV-L 13 (65%)
Hiring date: July 01, 2022
Duration of employment: 3 years
Contact: Univ.-Prof. Dr. Rudolf Leube
Email:, phone: +49 (0)241 80-89107
Equal career prospects for women and men.
Severely disabled applicants with equal qualification will be given preferential consideration.