Mechanobiology in Epithelial
3D Tissue Constructs


Department Institute of Molecular and Cellular Anatomy (MOCA)
Job site: RWTH Aachen University Hospital
Description of the position: PhD Position: Epidermal Tissue Stability in Keratinopathy
Job description: Our profile
Research at MOCA deals with the cytoskeleton as a main integrator of cell and tissue function. Particular emphasis is on the use of morphological and functional imaging techniques in vital cells, tissues and organisms (www.moca.ukaachen.de).

Your tasks
You will be part of the DFG-funded graduate school "Mechanobiology in Epithelial 3D Tissue Constructs" (MEŽT; me3t.rwth-aachen.de). You are expected to work in an interdisciplinary team with a keen interest in novel technological developments. Your project B2 "Consequences of disease-causing cytoskeletal mutations on epidermal tissue stability" combines 3D culture systems with state-of-the-art microscopy and mechanobiological analyses. You will monitor cytoskeletal keratin network dynamics, measure local mechanical properties and study mechanoresponses in wild-type and mutant keratinocytes grown as monolayers and epidermal equivalents.
Requirements / Your profile: We are looking for a highly motivated and ambitious PhD student with a strong background in cell biology or mechanobiology. Knowledge in the fields of biomaterials, tissue engineering and microscopy is appreciated, but no prerequisite. The successful applicant must have completed a master or equivalent degree in biology, biomedical engineering or a comparable study program to be accepted either as a Dr. rer. nat. or Dr. rer. medic. candidate at RWTH Aachen University. Willingness for teamwork, the ability to work independently and excellent English language skills are expected.
Pay category: TV-L 13 (65%)
Hiring date: July 01, 2019
Duration of employment: 3 years
Contact: Univ.-Prof. Dr. Rudolf Leube
Email: rleube@ukaachen.de, phone: +49 (0)241 80-89107
Web: www.moca.ukaachen.de
Equal career prospects for women and men.
Severely disabled applicants with equal qualification will be given preferential consideration.
Application deadline: March 31, 2019