Mechanobiology in Epithelial
3D Tissue Constructs


August 23-25, 2021

Announcement

 

 

Venue:

Webex

 

We are excited to share that registration and abstract submission for ‘Multiscale Mechanochemistry & Mechanobiology’ is now open.

 

As announced earlier this year, the conference will be a virtual event, hosted on Webex. Registration is free of charge, but required.

 

Approximately 25 slots are available for contributed talks (15 min incl. questions). In addition, we are planning two poster sessions on Gather.town.

Oral presentation abstract deadline:

June 30, 2021

Poster presentation abstract deadline:

August 15, 2021

 

Abstracts can be submitted by email, following the guidelines on the website.

 

We are looking forward to see many of you at the end of August.

 

Best wishes,

Kerstin Blank and Matt Harrin

August 1-8, 2021

Announcement

 

 

Intro to Computational Modeling & Python:

August 1st, 2021 (Sunday)

Summer School:

August 2nd – 6th, 2021 (Monday – Friday)

Model-Building Hackathon:

August 7th – 8th, 2021 (Saturday / Sunday)

Background:

Mechanistic modeling is an integral part of contemporary bioscience, used for hypothesis generation and testing, experiment design and interpretation, and the design of therapeutic interventions. The CompuCell3D modeling environment allow researchers with modest programing experience to rapidly build and execute complex Virtual Tissue simulations. With CompuCell3D you can simulate biology from the subcellular scale to the tissue scale. For instance, you can model tumor growth, what happens to tissues and cells when exposed to toxic compounds, viral spread in tissues, early embryonic development, intra- and extra-cellular biochemical networks, and more. CompuCell3D natively supports SBML and MaBoSS model integration. Try out models without any installation.

For more information please visit:

www.compucell3d.org

May 31-June 4, 2021

Announcement

 

 

Venue:

Maastricht, The Netherlands

 

Lorenzo Moroni - Chair (Maastricht University)

Liesbet Geris - co-chair (University of Liege)

Stefan Jockenhövel - co-chair (RWTH Aachen)

Learn about our
conference

https://www.termis.org

May 27, 2021

at 4.00 p.m

 

 

Speaker:

Ovijit Chaudhuri

 

Chaudhuri Lab for Cell Biophysics and Mechanotransduction

Stanford University, Stanford Engineering

https://chaudhurilab.stanford.edu

ZOOM-Session:

https://rwth.zoom.us/j/98194715525?pwd=enFPQ0JPeUM3dFBHVjhJdHZ4ZWdPUT09

Meeting-ID:

981 9471 5525

Passwort:

775502

Host:

Ramin Nasehi

Department of Dental Materials and Biomaterials Research (ZWBF)

Contact:

me3t@ukaachen.de

April 22, 2021

at 9.15 p.m

 

 

Speaker:

Benoit Ladoux

 

Université de Paris & CNRS

Institute Jacques Monod

ZOOM-Session:

https://rwth.zoom.us/j/99418690091?pwd=S 2E5emJVN1U1R0p6ZlNIcFhOc3NlZz09

Meeting-ID:

994 1869 0091

Passwort:

066958

Host:

Rudolf Leube

Institute of Molecular and Cellular Anatomy (MOCA)

Contact:

rleube@ukaachen.de

Abstract:

Active Nematic Behaviors of Cellular Monolayers

 

I will present how active nematic activity of cellular monolayers can help to understand biological processes and tissue organization.

 

In the first part, I will show how these active behaviors and stresses govern cell extrusion. By modelling the epithelium as an active nematic liquid crystal and measuring mechanical parameters such as strain rates and stresses measurements within cellular monolayers, I will show that apoptotic cell extrusion is provoked by singularities in cell alignments in the form of comet-shaped topological defects. These results highlight the importance of active nematic nature of epithelia.

 

In the second part, I will focus on the intriguing extensile behavior of epithelial cells as a collective when single cells behave as contractile systems. Through a combination of experiments and in silico modelling, we uncover the mechanism behind this switch of behavior of cell monolayers from extensile to contractile as the weakening of intercellular contacts. We find that this switch in active behavior also promotes the buildup of tension at the cell-substrate interface through an increase in actin stress fibers and higher traction forces. Such differences in extensility and contractility act to sort cells, thus determining a general mechanism for mechanobiological pattern formation.

February 15, 2021

Announcement

 

 

Dear Colleague,

We are delighted to inform you that the 3rd Conference on Multiscale Mechanochemistry and Mechanobiology will take place online and will be free of charge. Considering the still rather unpredictable development of the pandemic, we believe that this is the best option to keep everyone safe. We are planning with a large number contributed talks and posters and hope to see many old and new faces at what we expect to be a very exciting meeting. Please check here for details about the conference topics as well as updates on abstract submission.

 

As a primer for the conference, we are starting a Virtual Seminar Series with events every 5-6 weeks. Our first seminar will take place on Monday, Feb 15, 2021 at 15 CET (see below for details). We have a great line-up of speakers with contributions from Jeffrey Moore, Hai Qian and Yun Liu as well as Kris Dahl and Antoine Deblais. Registration is free, but required.

 

Last but not least, we are excited to announce the first Gordon Research Conference on Multiscale Mechanochemistry and Mechanobiology, which will take place in Ventura in the summer of 2022.

 

We hope to see many of you soon, either virtual in 2021 or in person in 2022!

 

Best wishes,

Matt Harrington and Kerstin Blank

February 25, 2021

 

 

 

Speaker:

Sirio Dupont

 

Department of Molecular Medicine, University of Padua

ZOOM-Session:

https://rwth.zoom.us/j/99154594806?pwd=elJwd1h0ZGxOY1NUR29qUnhCNzFhZz09

Meeting-ID:

991 5459 4806

Passwort:

848470

Host:

Mohamed Mabrouk

Helmholtz-Institute for Biomedical Engineering,

Division of Stem Cell Biology and Cellular Engineering

Contact:

me3t@ukaachen.de

 

 

 

December 17, 2020

Sven Ingebrandt: Transistor-based impedimetric monitoring of cell-substrate adhesion

 

Speaker

Sven Ingebrandt

 

 

Professor in Molecular Science & Engineering Rheinisch-Westfälische Technische Hochschule Aachen

Faculty of Electrical Engineering and Information Technology

 

Venue

ZOOM-Session

 

Host

Rudolf Leube

DWI – Leibniz Institute for Interactive Materials

 

Contact

rleube@ukaachen.de

 

 

 

November 05, 2020

Pieter Hiemstra: Lung epithelial cell culture models for studying respiratory infections in times of COVID-19

 

Speaker

Pieter Hiemstra

 

 

Professor Pulmonology, in particular cell biology and immunology of pulmonary diseases
Leiden University

https://www.universiteitleiden.nl/en/staffmembers/pi eter-hiemstra#tab-1

 

Venue

ZOOM-Session

 

 

 

October 15, 2020

David Mooney: Cells and Viscoelasticity

 

Speaker

David Mooney

 

 

Robert P. Pinkas Family Professor of Bioengineering

Harvard John A. Paulson School of Engineering and Applied Sciences

 

Venue

ZOOM-Session

 

Host

Laura De Laporte, Susan Babu

DWI – Leibniz Institute for Interactive Materials

 

 

 

September 03, 2020

Xavier Trepat: Mechanobiology of epithelial folding and migration in intestinal organoids

 

Speaker

Xavier Trepat

 

 

ICREA @ Institute for Bioengineering of Catalonia, Barcelona, Spain

http://www.ibecbarcelona.eu/integrative

 

Venue

ZOOM-Session

 

 

 

July 10, 2020

Michael Sheetz: Out of Touch - Depletion of Mechanosensors Drives Wound-Healing and Cancer

 

Speaker

Michael Sheetz

 

 

Welch Professor of Biochemistry

Molecular MechanoMedicine Program Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX

https://bmb.utmb.edu/bios/sheetz

 

Venue

ZOOM-Session

 

 

 

June 25, 2020

Ben Fabry: Collective forces of organoids, tumoroids and tumor spheroids in 3-dimensional matrices

 

Speaker

Ben Fabry

 

 

FAU Erlangen - Institut für Physik der Kondensierten Materie, Lehrstuhl für Biophysik

http://bio.physik.fau.de

 

Venue

ZOOM-Session

 

 

 

March 05, 2020

Ivan Bedzhov: Self-organization of the early mammalian embryo

 

Speaker

Ivan Bedzhov

 

 

Embryonic Self-Organization Research Group Max Planck Institute for Molecular Biomedicine

https://www.mpi-muenster.mpg.de/176301/bedzhov

 

Venue

Großer Seminarraum, Uniklinikum, Pauwelsstraße 30, 52074 Aachen

 

Abstract

After fertilization, the early embryo undergoes several rounds of divisions to form hollow-shaped blastocyst. The blastocyst contains pluripotent progenitors that will establish all the tissues of the fetus and multipotent stem cells that will give rise to the supportive extraembryonic tissues. The main function of the blastocyst is to initiate the process of implantation, which is a gateway for further development to term. However, the mammalian development at the time of implantation is largely unexplored as the maternal tissues completely engulf and conceal the embryo. Using the mouse as a model system, in combination with biomimetic platforms and embryonic stem cell techniques, we are trying to understand the process of self-organization of the embryonic tissues that dynamically acquire new shapes, functions and fates during the transition from pre- to post-implantation development.

 

 

 

March 03, 2020

Karsten Seidl: CMOS-based Micro and Nanosystems for Biomedical Applications

 

Speaker

Karsten Seidl

 

 

Fraunhofer Institute for Microelectronic Circuits and Systems, FhG-IMS, Duisburg

https://www.ims.fraunhofer.de/de/Presse/Presseinformationen/2019/Vorstellung_Karsten_Seidl_Biosensorik.html

 

Venue

Walter-Schottky-Haus, Sommerfeldstraße 24, 52074 Aachen, Room 24 C 104 (Seminar room S1)

 

Abstract

Karsten Seidl will talk about single-photon avalanche diodes (SPAD) for high-sensitive optical biosensors, nanoelectrodes for measuring intracellular potentials and pressure sensors for different biomedical applications.

 

 

 

February 20, 2020

Mike Boxem: Apical domain formation in C.elegans epithelia

 

Speaker

Mike Boxem

 

 

Developmental Biology Utrecht University

https://web.science.uu.nl/developmentalbiology/members/boxem.html

 

Venue

Großer Seminarraum, Raum 38a, MTI I, Institute of Pharmacology and Toxicology, Wendlingweg 2, 52074 Aachen

 

 

 

February 06, 2020

Thomas M. Magin: Insights into mechanical and regulatory functions of epidermal keratins

 

Speaker

Thomas M. Magin

 

 

Professor of Cell and Development Biology in the Institute of Biology, University of Leipzig

https://www.maginlab.eu

 

Venue

Großer Seminarraum, Uniklinikum, Pauwelsstraße 30, 52074 Aachen

 

 

 

January 23, 2020

Carsten Bolm: Mechanochemistry: Is there a link to mechanobiology?

 

Speaker

Carsten Bolm

 

 

Institute of Organic Chemistry

RWTH Aachen University

https://bolm.oc.rwth-aachen.de

 

Venue

Großer Seminarraum, Uniklinikum, Pauwelsstraße 30, 52074 Aachen

 

 

 

January 09, 2020

Jan Lammerding: Squish and squeeze – Nuclear mechanics in physiology and disease

 

Speaker

Jan Lammerding

 

 

Meinig School of Biomedical Engineering, Cornell University

http://lammerding.wicmb.cornell.edu

 

Venue

Großer Seminarraum, Uniklinikum, Pauwelsstraße 30, 52074 Aachen

 

Abstract

The nucleus is the characteristic feature of eukaryotic cells and houses the genomic information of the cell. The Lammerding laboratory is combining cell and molecular biology approaches with tissue engineering and microfabrication techniques, live-cell microscopy, and in vivo models to investigate the interplay between nuclear structure, mechanics, and function. In particular, the research is addressing how physical forces acting on the nucleus, for example, in contracting muscle cells or during migration of cells through tight interstitial spaces, can challenge the integrity of the nucleus, alter its structure, and cause genomic and transcriptional changes. I will present recent findings that demonstrate the importance of nuclear mechanics during cell migration in confined environments in vitro and in vivo, as well as the functional consequences of cells having to squeeze their large nuclei through tight interstitial spaces and small pores in the extracellular matrix network. In addition, I will discuss recent findings that highlight the importance of the nuclear envelope proteins lamins A/C in mediating nuclear stability and mechanotransduction in mechanically stressed cells and tissues, including how lamin mutations result in reduced nuclear stability, increased nuclear damage in striated muscle cells, and DNA damage and activation of DNA damage response pathways, which may explain the tissue-specific defects in diseases caused by lamin mutations. Insights gained from these studies could improve prognostic approaches and motivate novel therapeutic approaches for these diseases.

 

 

 

 

 

 

December 13, 2019

Jun. Prof. Dr. Peter Loskill's Presentation on Integrated Organ-on-a-chip systems: Advanced microphysiological platform recapitulating complex human tissue.

 

Speaker

Peter Loskill

 

 

Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB

Attract Group Leader Organ-on-a-Chip

www.igb.fraunhofer.de

 

Venue

Walter-Schottky-Haus, Sommerfeldstraße 24, 52074 Aachen, Room 24 C 104 (Seminar room S1)

 

 

 

December 12, 2019

Anna Taubenberger: Engineering 3D Microenvironments to Study Breast Tumor Spheroid Growth, Invasion and Mechanics

 

Speaker

Anna Taubenberger

 

 

Center for Molecular and Cellular Bioengineering (CMCB) Technische Universität Dresden

http://www.biotec.tu-dresden.de

 

Venue

Kursraum A033, Worringerweg 1, 52074 Aachen

 

 

 

November 22, 2019

Prof. Dr.-Ing. Michael J. Vellekoop's Presentation on Microfluidics for Bioanalysis.

 

Speaker

Michael J. Vellekoop

 

 

Institut für Mikrosensoren, -aktoren und -systeme (IMSAS), Universität Bremen

 

Venue

Walter-Schottky-Haus, Sommerfeldstraße 24, 52074 Aachen, Room 24 C 102 (Seminar room S2)

 

 

 

September 26, 2019

Paul Wieringa: Biofabrication Strategies for Peripheral Nerve Engineering

 

Speaker

Paul Wieringa

 

 

Institute for Technology-Inspired Regenerative Medicine

https://www.moronilab.org/

 

Venue

Großer Seminarraum 38a, MTI 2, Institute of Pharmacology and Toxicology

Wendlingweg 2, 52074 Aachen

 

Host

Ruolf Leube 

Institute of Molecular and Cellular Anatomy (MOCA)

 

 

 

September 12, 2019

Prof. Dr. Boris Martinac: Piezo1 mechanosensitive ion channels: What are they and why are they important

 

Speaker

Boris Martinac

 

 

Head of Mechanosensory Biophysics Laboratory

Victor Chang Cardiac Research Institute, Sydney, Australia

www.victorchang.edu.au

 

Venue

Großer Seminarraum 38a, MTI 2, Institute of Pharmacology and Toxicology

Wendlingweg 2, 52074 Aachen

 

Host

I. Classen-Linke

iclassen-linke@ukaachen.de 

 

 

 

February 18, 2021

 

 

 

Speaker:

Paul Steinmann and Silvia Budday

 

Institute of Applied Mechanics

Friedrich-Alexander University Erlangen-Nürnberg

ZOOM-Session:

https://rwth.zoom.us/j/91373023958?pwd=NGdab3FkUE9QaTFTb2dnejZUeWJaUT09

Passwort:

483892

Host:

Ana-Suncana Smith

PULS Group, Institute for Theoretical Physics, FAU Erlangen

Contact:

smith@physik.fau.de